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Abstract

The Canadian Sentinel Practitioner Surveillance Network estimated vaccine effectiveness (VE) during the unusually early 2022/23 influenza A(H3N2) epidemic. Like vaccine, circulating viruses were clade 3C.2a1b.2a.2, but with genetic diversity affecting haemagglutinin positions 135 and 156, and reassortment such that H156 viruses acquired neuraminidase from clade 3C.2a1b.1a. Vaccine provided substantial protection with A(H3N2) VE of 54% (95% CI: 38 to 66) overall. VE was similar against H156 and vaccine-like S156 viruses, but with potential variation based on diversity at position 135.

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2023-02-02
2024-04-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.5.2300043
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Vaccine effectiveness estimates from an early-season influenza A(H3N2) epidemic, including unique genetic diversity with reassortment, Canada, 2022/23
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Danuta+M+Skowronski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skowronski Danuta M</a>, <a href="/search?value1=Erica+SY+Chuang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chuang Erica SY</a>, <a href="/search?value1=Suzana+Sabaiduc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sabaiduc Suzana</a>, <a href="/search?value1=Samantha+E+Kaweski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kaweski Samantha E</a>, <a href="/search?value1=Shinhye+Kim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kim Shinhye</a>, <a href="/search?value1=James+A+Dickinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dickinson James A</a>, <a href="/search?value1=Romy+Olsha&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Olsha Romy</a>, <a href="/search?value1=Jonathan+B+Gubbay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubbay Jonathan B</a>, <a href="/search?value1=Nathan+Zelyas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zelyas Nathan</a>, <a href="/search?value1=Hugues+Charest&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Charest Hugues</a>, <a href="/search?value1=Nathalie+Bastien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bastien Nathalie</a>, <a href="/search?value1=Agatha+N+Jassem&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jassem Agatha N</a>, <a href="/search?value1=Gaston+De+Serres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Serres Gaston</a></span>. Vaccine effectiveness estimates from an early-season influenza A(H3N2) epidemic, including unique genetic diversity with reassortment, Canada, 2022/23. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(5):pii=2300043. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.5.2300043" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.5.2300043</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 23 Jan 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 02 Feb 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.5.2300043
/content/10.2807/1560-7917.ES.2023.28.5.2300043
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