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Abstract

Background

Data on economic costs of respiratory syncytial virus (RSV) infections among children in primary care are scarce, although most RSV-infections are managed in this setting.

Aim

To estimate outpatient costs for RSV-positive children aged < 5 years.

Methods

In the RSV ComNet prospective cohort, children < 5 years with acute respiratory infection were recruited for RSV testing through primary care physicians in Belgium, Italy, the Netherlands, Spain and the United Kingdom (UK) during RSV seasons 2020/21 (UK only), 2021/22 and 2022/23. Outpatient healthcare utilisation and parental work absence were assessed over 30 days through parental questionnaires. Average costs per RSV episode were calculated from outpatient healthcare sector and societal perspectives, stratified by country and age.

Results

We included 3,414 children and 1,124 (33%) tested RSV-positive. Physicians completed reports for 878 episodes, with follow-up questionnaire data for 819 (93%). Outpatient costs ranged from EUR 97 (95% CI: 91–104) in the Netherlands to EUR 300 (95% CI: 287–312) in Spain and were higher for infants than children aged 1–5 years. Societal costs ranged from EUR 454 (95% CI: 418–494) in the UK to EUR 994 (95% CI: 938–1,053) in Belgium. For children aged 1–5 years, societal costs were primarily driven by parental work absence. In infants, the main societal cost driver varied by country, but overall outpatient healthcare costs represented a higher proportion of societal costs vs older children.

Conclusion

RSV infections in children attending primary care result in substantial economic costs per episode, although differences exist across countries. This study provides essential data to inform cost-effectiveness analyses on novel RSV immunisations.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2025-05-22
2025-05-23
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Economic impact of RSV infections in young children attending primary care: a prospective cohort study in five European countries, 2021 to 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Val%C3%A9rie+DV+Sankatsing&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sankatsing Valérie DV</a>, <a href="/search?value1=Sarah+F+Hak&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hak Sarah F</a>, <a href="/search?value1=Joanne+G+Wildenbeest&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wildenbeest Joanne G</a>, <a href="/search?value1=Roderick+P+Venekamp&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Venekamp Roderick P</a>, <a href="/search?value1=Mauro+Pistello&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pistello Mauro</a>, <a href="/search?value1=Caterina+Rizzo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rizzo Caterina</a>, <a href="/search?value1=Santiago+Alfayate-Migu%C3%A9lez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alfayate-Miguélez Santiago</a>, <a href="/search?value1=Daan+Van+Brusselen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Brusselen Daan</a>, <a href="/search?value1=Marta+Carballal-Mari%C3%B1o&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carballal-Mariño Marta</a>, <a href="/search?value1=Uy+Hoang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoang Uy</a>, <a href="/search?value1=Rolf+Kramer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kramer Rolf</a>, <a href="/search?value1=Simon+de+Lusignan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Lusignan Simon</a>, <a href="/search?value1=Oliver+Martyn&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Martyn Oliver</a>, <a href="/search?value1=Marc+Raes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Raes Marc</a>, <a href="/search?value1=Adam+Meijer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Meijer Adam</a>, <a href="/search?value1=on+behalf+of+the+RSV+ComNet+Network&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the RSV ComNet Network</a>, <a href="/search?value1=Jojanneke+van+Summeren&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Summeren Jojanneke</a></span>. Economic impact of RSV infections in young children attending primary care: a prospective cohort study in five European countries, 2021 to 2023. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(20):pii=2400797. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.20.2400797" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.20.2400797</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 Dec 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Apr 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.20.2400797
/content/10.2807/1560-7917.ES.2025.30.20.2400797
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