1887
Rapid communication Open Access
Like 0
This item has no PDF Download

Abstract

We report four cases of severe neonatal non-polio enterovirus infection, requiring hospital admission. Infants presented to different regional hospitals across Northern Ireland from late 2024 to early 2025. Three had neonatal meningitis and one showed rapid demise, leading to sepsis, multi-organ failure and death at day 6 of life. All infants were less than 18 days old at presentation, two were considered congenital infections, with one presenting symptoms at birth. All infants had detectable enterovirus RNA, typed as coxsackievirus B4.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2025.30.21.2500317
2025-05-29
2025-06-03
/content/10.2807/1560-7917.ES.2025.30.21.2500317
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/30/21/eurosurv-30-21-1.html?itemId=/content/10.2807/1560-7917.ES.2025.30.21.2500317&mimeType=html&fmt=ahah

References

  1. Pattanaik A, Bhandarkar B S, v S, Mukhopadhyay C. Recent cluster of neonatal enteroviral myocarditis cases in the United Kingdom of Great Britain and Northern Ireland - current scenario and counteracting prospects. IJID Reg. 2024;10:197-9.  https://doi.org/10.1016/j.ijregi.2024.01.009  PMID: 38356998 
  2. European Centre for Disease Prevention and Control (ECDC). Epidemiological update: Echovirus 11 infections in neonates. Stockholm: ECDC; 2023. Available from: https://www.ecdc.europa.eu/en/news-events/epidemiological-update-echovirus-11-infections-neonates
  3. Feeney SA, Christie S, Beard S, Hill L, Speirs L, McKenna JP. Neonatal EV Infection case of Echovirus 11 (E11) ESCV 2023, ENPEN Session, Milan 20 Aug-2 Sept 2023, Oral Presentation.
  4. Arthur J, Ali S, Okoye G, Egyepong J, Mapa S, Akhtar F, et al. Congenital enterovirus infection case series: early recognition can improve outcome. Infant. 2021;17(1):13-7. Available from: https://www.infantjournal.co.uk/journal_article.html?id=7198
  5. Chuang YY, Huang YC. Enteroviral infection in neonates. J Microbiol Immunol Infect. 2019;52(6):851-7.  https://doi.org/10.1016/j.jmii.2019.08.018  PMID: 31607572 
  6. Majumdar M, Celma C, Pegg E, Polra K, Dunning J, Martin J. Detection and typing of human enterovirus from clinical sample by entire-capsid Next Generation Sequencing. Viruses. 2021;13(4):641.  https://doi.org/10.3390/v13040641  PMID: 33918088 
  7. National Institute for Health and Care Excellence (NICE). Neonatal infection (early onset) antibiotics for prevention and treatment. Clinical Guideline CG149:2012. Manchester: NICE; 2012. Available from: https://www.nice.org.uk/guidance/ng195
  8. Méreaux J, Picone O, Vauloup-Fellous C, Khediri Z, Benachi A, Mandelbrot L, et al. L’infection à entérovirus durant la grossesse : une cause sous-estimée de complications fœtale et néonatale? [Enterovirus infection during pregnancy: Underestimated cause of fetal and neonatal complications?] Gynecol Obstet Fertil Senol. 2017;45(4):231-7. French.  https://doi.org/10.1016/j.gofs.2017.02.004  PMID: 28373042 
  9. Kohil A, Jemmieh S, Smatti MK, Yassine HM. Viral meningitis: an overview. Arch Virol. 2021;166(2):335-45.  https://doi.org/10.1007/s00705-020-04891-1  PMID: 33392820 
  10. Zhang M, Wang H, Tang J, He Y, Xiong T, Li W, et al. Clinical characteristics of severe neonatal enterovirus infection: a systematic review. BMC Pediatr. 2021;21(1):127.  https://doi.org/10.1186/s12887-021-02599-y  PMID: 33722228 
  11. Yen MH, Huang YC, Chen MC, Liu CC, Chiu NC, Lien R, et al. Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration. J Clin Virol. 2015;64:92-6.  https://doi.org/10.1016/j.jcv.2015.01.013  PMID: 25728086 
  12. Torres-Torres S, Myers AL, Klatte JM, Rhoden EE, Oberste MS, Collett MS, et al. First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis. Pediatr Infect Dis J. 2015;34(1):52-4.  https://doi.org/10.1097/INF.0000000000000497  PMID: 25229269 
  13. Cataldi J, Rhoden E, Oberste S, Hincks K, Collett M, Wright C, et al. Use of investigational antiviral drug Pocapavir to treat enterovirus sepsis in win neonates. Open Forum Infect Dis. 2015;2(1):478.  https://doi.org/10.1093/ofid/ofv133.353 
  14. UK Health Security Agency (UKHSA). Changes to health notification regulations (NOIDS). London: UKHSA; 2025. Available from: https://ukhsa.blog.gov.uk/2025/03/11/changes-to-health-protection-notification-regulations
  15. Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, et al. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe. J Clin Virol. 2018;101:11-7.  https://doi.org/10.1016/j.jcv.2018.01.008  PMID: 29414181 
  16. Fischer TK, Simmonds P, Harvala H. The importance of enterovirus surveillance in a post-polio world. Lancet Infect Dis. 2022;22(1):e35-40.  https://doi.org/10.1016/S1473-3099(20)30852-5  PMID: 34265258 
  17. Bubba L, Broberg EK, Jasir A, Simmonds P, Harvala H, Redlberger-Fritz M, et al. Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study. Lancet Infect Dis. 2020;20(3):350-61.  https://doi.org/10.1016/S1473-3099(19)30566-3  PMID: 31870905 
  18. Chuang YY, Huang YC. Enteroviral infection in neonates. J Microbiol Immunol Infect. 2019;52(6):851-7.  https://doi.org/10.1016/j.jmii.2019.08.018  PMID: 31607572 
  19. Richman D, Whitley R, Hayden F. Enteroviruses. Clinical Virology. 4th ed. Wiley Online Library. 2016. p1113-1142.  https://doi.org/10.1128/9781555815981.ch45 
/content/10.2807/1560-7917.ES.2025.30.21.2500317
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error