Editorial Open Access
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2025.30.26.2500454
Like 0
Access full text
Article
-
Doxycycline post-exposure prophylaxis (doxyPEP): balancing promise and prudence in the prevention of sexually transmitted infections
- Fiona Lyons,1,2,3 , Adam Shanley3
-
View Affiliations Hide AffiliationsAffiliations: 1 Department of Genitourinary Medicine and Infectious Diseases, St. James’s Hospital, Dublin, Ireland 2 Sexual Health Programme, Health Service Executive, Dublin, Ireland 3 School of Medicine, Trinity College Dublin, Dublin, IrelandFiona LyonsFionae.Lyons hse.ie
-
View Citation Hide Citation
Citation style for this article: Lyons, Fiona, Shanley Adam. Doxycycline post-exposure prophylaxis (doxyPEP): balancing promise and prudence in the prevention of sexually transmitted infections. Euro Surveill. 2025;30(26):pii=2500454. https://doi.org/10.2807/1560-7917.ES.2025.30.26.2500454 Received: 30 Jun 2025; Accepted: 03 Jul 2025
Preview this article:




Doxycycline post-exposure prophylaxis (doxyPEP): balancing promise and prudence in the prevention of sexually transmitted infections, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/30/26/eurosurv-30-26-1-1.gif
There is no abstract available.

Article metrics loading...
/content/10.2807/1560-7917.ES.2025.30.26.2500454
2025-07-03
2025-07-04
/content/10.2807/1560-7917.ES.2025.30.26.2500454


Full text loading...
/deliver/fulltext/eurosurveillance/30/26/eurosurv-30-26-1.html?itemId=/content/10.2807/1560-7917.ES.2025.30.26.2500454&mimeType=html&fmt=ahah
References
-
European Centre for Disease Prevention and Control (ECDC). STI cases continue to rise across Europe. Stockholm: ECDC; 10 Feb 2025. Available from: https://www.ecdc.europa.eu/en/news-events/sti-cases-continue-rise-across-europe
-
World Health Organization (WHO). Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022-2030. Geneva: WHO; 2022. Available from: https://www.who.int/publications/i/item/9789240053779
-
Molina JM, Charreau I, Chidiac C, Pialoux G, Cua E, Delaugerre C, et al. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis. 2018;18(3):308-17. https://doi.org/10.1016/S1473-3099(17)30725-9 PMID: 29229440
-
Luetkemeyer AF, Donnell D, Dombrowski JC, Cohen S, Grabow C, Brown CE, et al. Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections. N Engl J Med. 2023;388(14):1296-306. https://doi.org/10.1056/NEJMoa2211934 PMID: 37018493
-
Molina JM, Bercot B, Assoumou L, Rubenstein E, Algarte-Genin M, Pialoux G, et al. Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design. Lancet Infect Dis. 2024;24(10):1093-104. https://doi.org/10.1016/S1473-3099(24)00236-6 PMID: 38797183
-
Raccagni AR, Diotallevi S, Lolatto R, Bruzzesi E, Catalano G, Mainardi I, et al. DoxyPEP: real-life effectiveness in a cohort of men who have sex with men in Milan, Italy. Lancet Infect Dis. 2025;25(1):e1-3. https://doi.org/10.1016/S1473-3099(24)00726-6 PMID: 39577454
-
Saunders J, Deering J, Dewsnap C, Drayton R, Gilmore J, Grant A, et al. British Association for Sexual Health and HIV (BASHH) UK national guideline for the use of doxycycline post-exposure prophylaxis (DoxyPEP) for the prevention of syphilis, 2025. Int J STD AIDS. 2025:9564624251352053. https://doi.org/10.1177/09564624251352053 PMID: 40505019
-
Bachmann LH, Barbee LA, Chan P, Reno H, Workowski KA, Hoover K, et al. CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024. MMWR Recomm Rep. 2024;73(2):1-8. https://doi.org/10.15585/mmwr.rr7302a1 PMID: 38833414
-
Cornelisse VJ, Riley B, Medland NA. Australian consensus statement on doxycycline post-exposure prophylaxis (doxy-PEP) for the prevention of syphilis, chlamydia and gonorrhoea among gay, bisexual and other men who have sex with men. Med J Aust. 2024;220(7):381-6. https://doi.org/10.5694/mja2.52258 PMID: 38479437
-
Werner RN, Schmidt AJ, Potthoff A, Spornraft-Ragaller P, Brockmeyer NH, German STI, et al. Position statement of the German STI Society on the prophylactic use of doxycycline to prevent STIs (Doxy-PEP, Doxy-PrEP). J Dtsch Dermatol Ges. 2024;22(3):466-78. https://doi.org/10.1111/ddg.15282 PMID: 38123738
-
SOAIDS Nederland SOAIDS. Nederlandse stellingname inzake doxyPEP. [Dutch position on doxyPEP]. Amsterdam: SOAIDS Nederland; Jan 2025. Dutch. Available from: https://www.soaaids.nl/files/2025-01/Nederlandse%20stellingname%20DoxyPEP%20jan2025%20DEFINITIEF%20webversie.pdf
-
Sherrard J, Gokengin D, Winter A, Marks M, Unemo M, Jensen JS, et al. IUSTI Europe position statement on use of DoxyPEP: June 2024. Int J STD AIDS. 2024;35(13):1087-9. https://doi.org/10.1177/09564624241273801 PMID: 39167417
-
World Health Organization (WHO). WHO announces the development of recommendations on doxycycline prophylaxis for the prevention of sexually transmitted infections. Geneva: WHO; 28 May 2025. Available from: https://www.who.int/news/item/28-05-2025-who-announces-the-development-of-recommendations-on-doxycycline-prophylaxis-for-the-prevention-of-sexually-transmitted-infections#:~:text=WHO%20is%20convening%20a%20Guideline,sexually%20transmitted%20infections%20(STIs)
-
Mårdh O, Plachouras D. Using doxycycline for prophylaxis of bacterial sexually transmitted infections: considerations for the European Union and European Economic Area. Euro Surveill. 2023;28(46):2300621. https://doi.org/10.2807/1560-7917.ES.2023.28.46.2300621 PMID: 37971658
-
Teker B, Hoornenborg E, Schim van der Loeff MF, Boyd A, Heijne JCM, Prins M, et al. Emergent informal use of doxycycline post- and pre-exposure prophylaxis among men who have sex with men and transgender and gender diverse people, the Netherlands, 2024. Euro Surveill. 2025;30(26):2400707. https://doi.org/10.2807/1560-7917.ES.2025.30.26.2400707
-
Tsoumanis A, Hens N, Kenyon CR. Is Screening for Chlamydia and Gonorrhea in Men Who Have Sex With Men Associated With Reduction of the Prevalence of these Infections? A Systematic Review of Observational Studies. Sex Transm Dis. 2018;45(9):615-22. https://doi.org/10.1097/OLQ.0000000000000824 PMID: 29485537
-
Williams E, Williamson DA, Hocking JS. Frequent screening for asymptomatic chlamydia and gonorrhoea infections in men who have sex with men: time to re-evaluate? Lancet Infect Dis. 2023;23(12):e558-66. https://doi.org/10.1016/S1473-3099(23)00356-0 PMID: 37516129
-
Van Praet JT, Henrard S, Kenyon C, Libois A, Meuwissen A, Sauvage AS, et al. Belgian 2024 guidance on the use of pre-exposure prophylaxis. Acta Clin Belg. 2024;79(2):121-9. https://doi.org/10.1080/17843286.2024.2356337 PMID: 38775082
-
National Institute for Public Health and the Environment (RIVM). 11-7-2024 Verandering testbeleid Chlamydia. [11-7-2024 Change in Chlamydia testing policy]. Bilthoven: RIVM; 11 Jul 2024. Dutch. Available from: https://www.rivm.nl/soa/actueel
-
Fredericksen RJ, Perkins R, Brown CE, Cannon C, Lopez C, Cohee A, et al. Doxycycline as Postsexual Exposure Prophylaxis: Use, Acceptability, and Associated Sexual Health Behaviors Among a Multi-Site Sample of Clinical Trial Participants. AIDS Patient Care STDs. 2024;38(4):155-67. https://doi.org/10.1089/apc.2023.0289 PMID: 38656217
-
Chan PA, Malyuta Y, Parent H, Tao J, Erbe M, Salhaney P, et al. Early adopters of doxycycline as post-exposure prophylaxis to prevent bacterial sexually transmitted infections in a real-world clinical setting. Sex Transm Infect. 2024;100(6):339-42. https://doi.org/10.1136/sextrans-2024-056152 PMID: 38821877
-
Villanueva Baselga S, Ruben M, Luis V. A practice already in use: a snapshot survey on the use of doxycycline as a preventive strategy (Doxy-PEP and Doxy-PrEP) in the GBMSM population in Spain. Infection. 2025;53(1):437-41. https://doi.org/10.1007/s15010-024-02320-y PMID: 39060908
-
Ehsan R, D’Angelo AB, Westmoreland DA, Grov C. Perceptions about doxycycline post-exposure prophylaxis (Doxy-PEP) as an STI-prevention strategy among gay and bisexual men (GBM) in the United States: Results from a qualitative study. Prev Med. 2024;183:107977. https://doi.org/10.1016/j.ypmed.2024.107977 PMID: 38692309
-
Horn R, Callander D, Haire B. Perceptions of sexually transmissible infection pre-exposure prophylaxis: a qualitative study of high-risk gay and bisexual men in Sydney, New South Wales. Sex Health. 2020;17(2):129-34. https://doi.org/10.1071/SH19175 PMID: 32213272
-
Dillon C, O’Donnell K, McKeown P, Lyons F, Browne C, Fallon U, et al. Mpox outbreak - Response and epidemiology of confirmed cases in Ireland from May 2022 to May 2023. Ir Med J. 2024;117(6):975. PMID: 39041467
Submit comment
Close
