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SDG 3: STI

Abstract

is an emerging difficult to diagnose dermatophyte species associated with terbinafine resistance, which was initially described in South-Asian and Middle-Eastern countries. We report four cases of sexually transmitted dermatophytosis caused by in two female sex-workers, including one transgender woman, and two men who have sex with men. All four cases were acquired in Europe, highlighting the risk of pathogen spread through sexual contact outside initial endemic areas.

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2025-07-03
2025-07-19
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References

  1. Jabet A, Normand AC, Brun S, Dannaoui E, Bachmeyer C, Piarroux R, et al. Trichophyton indotineae, from epidemiology to therapeutic. J Mycol Med. 2023;33(3):101383.  https://doi.org/10.1016/j.mycmed.2023.101383  PMID: 37031652 
  2. Jabet A, Bérot V, Chiarabini T, Dellière S, Bosshard PP, Siguier M, et al. Trichophyton mentagrophytes ITS genotype VII infections among men who have sex with men in France: An ongoing phenomenon. J Eur Acad Dermatol Venereol. 2025;39(2):407-15.  https://doi.org/10.1111/jdv.20439  PMID: 39587983 
  3. Bortoluzzi P, Aromolo IF, Derlino F, Marzano AV, Perego G. Tinea barbae caused by T. mentagrophytes genotype VII, an emerging sexually transmitted infection among Men who have Sex with Men: A report from Milan, Italy. J Eur Acad Dermatol Venereol. 2025;39(2):e187-90.  https://doi.org/10.1111/jdv.20395  PMID: 39587982 
  4. Descalzo V, Martín MT, Álvarez-López P, García-Pérez JN, Alcázar-Fuoli L, López-Pérez L, et al. Trichophyton mentagrophytes genotype VII and sexually transmitted tinea: an observational study in Spain. Mycoses. 2025;68(4):e70049.  https://doi.org/10.1111/myc.70049  PMID: 40156344 
  5. Zucker J, Caplan AS, Gunaratne SH, Gallitano SM, Zampella JG, Otto C, et al. Notes from the field: Trichophyton mentagrophytes genotype VII - New York City, April-July 2024. MMWR Morb Mortal Wkly Rep. 2024;73(43):985-8.  https://doi.org/10.15585/mmwr.mm7343a5  PMID: 39480750 
  6. Normand AC, Moreno-Sabater A, Jabet A, Hamane S, Cremer G, Foulet F, et al. MALDI-TOF mass spectrometry online identification of Trichophyton indotineae using the MSI-2 application. J Fungi (Basel). 2022;8(10):1103.  https://doi.org/10.3390/jof8101103  PMID: 36294668 
  7. Yamada T, Maeda M, Alshahni MM, Tanaka R, Yaguchi T, Bontems O, et al. Terbinafine resistance of Trichophyton clinical isolates caused by specific point mutations in the squalene epoxidase gene. Antimicrob Agents Chemother. 2017;61(7):e00115-17.  https://doi.org/10.1128/AAC.00115-17  PMID: 28416557 
  8. Dellière S, Jabet A, Abdolrasouli A. Current and emerging issues in dermatophyte infections. PLoS Pathog. 2024;20(6):e1012258.  https://doi.org/10.1371/journal.ppat.1012258  PMID: 38870096 
  9. Jabet A, Dellière S, Seang S, Chermak A, Schneider L, Chiarabini T, et al. Sexually Transmitted Trichophyton mentagrophytes Genotype VII Infection among Men Who Have Sex with Men. Emerg Infect Dis. 2023;29(7):1411-4.  https://doi.org/10.3201/eid2907.230025  PMID: 37347803 
  10. Porquet A, Wirbel C, Godinot M, Persat F, Menotti J, Danset M, et al. Dermatophytoses à Trichophyton mentagrophytes de génotype VII : une IST émergente de présentation clinique polymorphe. [Dermatophytoses due to Trichophyton mentagrophytes genotype VII: an emerging STI with polymorphic clinical presentation]. Annales de Dermatologie et de Vénéréologie - FMC. 2024;4(8S1):A237. French.  https://doi.org/10.1016/j.fander.2024.09.064 
  11. Werner RN, Zeyen C, Nast A. Trichophyton mentagrophytes genotype VII – an emerging sexually transmitted fungal infection relevant for men who have sex with men. EADV Congress; 2023 Oct 11; Berlin.
  12. Abdolrasouli A, Curtis C, Macrae B, Oroz C, Cunningham M, Gkini MA, et al. Emerging Trichophyton mentagrophytes genotype VII in the United Kingdom. J Eur Acad Dermatol Venereol. 2025;jdv.20803.  https://doi.org/10.1111/jdv.20803  PMID: 40539718 
  13. Kapranou R, Kotsafti O, Vrioni G, Giannoukos A, Papanikou S, Stratigos A, et al. Trichophyton Mentagrophytes type VII (TMVII): an emerging sexually transmitted pathogen. QJM. 2025;hcaf049.  https://doi.org/10.1093/qjmed/hcaf049  PMID: 39951293 
  14. Otero L, Palacio V, Vázquez F. Tinea cruris in female prostitutes. Mycopathologia. 2002;153(1):29-31.  https://doi.org/10.1023/A:1015257320824  PMID: 11913763 
  15. European Centre for Disease Prevention and Control (ECDC). Communicable disease threats report, 14-17 May 2023, week 20. Stockholm: ECDC; 2023. Available from: https://www.ecdc.europa.eu/en/publications-data/communicable-disease-threats-report-14-17-may-2023-week-20
  16. Ferreira CB, Lisboa C. A systematic review on the emergence of terbinafine-resistant Trichophyton indotineae in Europe: Time to act? J Eur Acad Dermatol Venereol. 2025;39(2):364-76.  https://doi.org/10.1111/jdv.20270  PMID: 39082800 
  17. Durdu M, Kandemir H, Karakoyun AS, Ilkit M, Tang C, de Hoog S. First terbinafine-resistant Trichophyton indotineae isolates with Phe397Leu and/or Thr414His mutations in Turkey. Mycopathologia. 2023;188(1):2.  https://doi.org/10.1007/s11046-023-00708-2  PMID: 36656402 
  18. Buil JB, Meijer EFJ, den Reijer M, Zeeuwen-Franssen MEJ, Melchers WJG, Verweij PE. Hardnekkige dermatomycose doorTrichophyton indotineae. [Persistent dermatomycosis due toTrichophyton indotineae]. Ned Tijdschr Geneeskd. 2024;168:D7945. Dutch. PMID: 39087461 
  19. Carroll E, Leahy M, Stanciu M, Laing M. Trichophyton indotineae: first case in Ireland and response to topical griseofulvin. Clin Exp Dermatol. 2024;49(12):1707-8.  https://doi.org/10.1093/ced/llae264  PMID: 39005069 
  20. Kolarczyková D, Lysková P, Švarcová M, Kuklová I, Dobiáš R, Mallátová N, et al. Terbinafine resistance in Trichophyton mentagrophytes and Trichophyton rubrum in the Czech Republic: A prospective multicentric study. Mycoses. 2024;67(2):e13708.  https://doi.org/10.1111/myc.13708  PMID: 38404204 
  21. Sacheli R, Egrek S, El Moussaoui K, Darfouf R, Adjetey AB, Hayette MP. Evaluation of currently available laboratory methods to detect terbinafine resistant dermatophytes including a gradient strip for terbinafine, EUCAST microdilution E.Def 11.0, a commercial real-time PCR assay, squalene epoxidase sequencing and whole genome sequencing. Mycoses. 2024;67(12):e70005.  https://doi.org/10.1111/myc.70005  PMID: 39658811 
  22. Abdolrasouli A, Barton RC, Borman AM. Spread of antifungal-resistant Trichophyton indotineae, United Kingdom, 2017-2024. Emerg Infect Dis. 2025;31(1):192-4.  https://doi.org/10.3201/eid3101.240923  PMID: 39714510 
  23. Duus L, Schachsen PK, Gertsen JB, Astvad KMT, Kristensen L. Terbinafine resistance in Trichophyton species from patients with recalcitrant infections detected by the EUCAST broth microdilution method and DermaGenius resistance multiplex PCR kit. Mycoses. 2025;68(1):e70011.  https://doi.org/10.1111/myc.70011  PMID: 39734267 
  24. Mohseni S, Abou-Chakra N, Oldberg K, Chryssanthou E, Young E. Terbinafine resistant Trichophyton indotineae in Sweden. Acta Derm Venereol. 2025;105:adv42089.  https://doi.org/10.2340/actadv.v105.42089  PMID: 39927724 
  25. Sun L, Ferreira J, Vidal B, Veríssimo C, Sabino R, Marques T, et al. Extensive recalcitrant tinea corporis caused by Trichophyton indotineae. Mycopathologia. 2025;190(1):20.  https://doi.org/10.1007/s11046-024-00927-1  PMID: 39873843 
  26. Tóth Z, Ványai B, Kovács R, Jakab Á, Szegedi A, Balázs B, et al. First report of Trichophyton indotineae infection in Hungary. J Fungi (Basel). 2025;11(4):248.  https://doi.org/10.3390/jof11040248  PMID: 40278069 
  27. Moreno-Sabater A, Normand AC, Bidaud AL, Cremer G, Foulet F, Brun S, et al. Terbinafine resistance in dermatophytes: a French multicenter prospective study. J Fungi (Basel). 2022;8(3):220.  https://doi.org/10.3390/jof8030220  PMID: 35330222 
  28. Messina F, Santiso G, Romero M, Bonifaz A, Fernandez M, Marin E. First case report of tinea corporis caused by Trichophyton indotineae in Latin America. Med Mycol Case Rep. 2023;41:48-51.  https://doi.org/10.1016/j.mmcr.2023.08.004  PMID: 37706043 
  29. Xie W, Kong X, Zheng H, Mei H, Ge N, Hu S, et al. Rapid emergence of recalcitrant dermatophytosis caused by a cluster of multidrug-resistant Trichophyton indotineae in China. Br J Dermatol. 2024;190(4):585-7.  https://doi.org/10.1093/bjd/ljae009  PMID: 38180270 
  30. Spivack S, Gold JAW, Lockhart SR, Anand P, Quilter LAS, Smith DJ, et al. Potential sexual transmission of antifungal-resistant Trichophyton indotineae. Emerg Infect Dis. 2024;30(4):807-9.  https://doi.org/10.3201/eid3004.240115  PMID: 38437706 
  31. Jabet A, Monfort JB, Hennequin C, Fekkar A, Piarroux R, Normand AC. Trichophyton indotineae infection with toenail onychomycosis. Clin Exp Dermatol. 2025;50(7):1421-2.  https://doi.org/10.1093/ced/llaf089  PMID: 39988977 
Autochthonous transmission of Trichophyton indotineae through sexual contact, France, 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Arnaud+Jabet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jabet Arnaud</a>, <a href="/search?value1=Thibault+Chiarabini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chiarabini Thibault</a>, <a href="/search?value1=Christophe+Hennequin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hennequin Christophe</a>, <a href="/search?value1=Fabrice+Bouscarat&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bouscarat Fabrice</a>, <a href="/search?value1=Nadia+Valin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valin Nadia</a>, <a href="/search?value1=Romuald+Cruchet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cruchet Romuald</a>, <a href="/search?value1=Nicolas+Boo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Boo Nicolas</a>, <a href="/search?value1=Johan+Chanal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chanal Johan</a>, <a href="/search?value1=Christine+Schuttler&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schuttler Christine</a>, <a href="/search?value1=Myriam+Kirstetter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kirstetter Myriam</a>, <a href="/search?value1=Anne-C%C3%A9cile+Normand&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Normand Anne-Cécile</a>, <a href="/search?value1=Arnaud+Fekkar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fekkar Arnaud</a>, <a href="/search?value1=Val%C3%A9rie+Pourcher&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pourcher Valérie</a>, <a href="/search?value1=Renaud+Piarroux&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Piarroux Renaud</a>, <a href="/search?value1=Gentiane+Monsel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monsel Gentiane</a></span>. Autochthonous transmission of Trichophyton indotineae through sexual contact, France, 2024. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(26):pii=2500416. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.26.2500416" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.26.2500416</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Jun 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 30 Jun 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.26.2500416
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